Linear Low-Dose Extrapolation for Noncancer Responses Is Not Generally Appropriate
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چکیده
منابع مشابه
Linear Low-Dose Extrapolation for Noncancer Responses Is Not Generally Appropriate
A 140 volume 117 | number 4 | April 2009 • Environmental Health Perspectives PAH Exposure doi:10.1289/ehp.0800445 We were very interested to read the article by Choi et al. (2008). The difference between maternal exposure and our own data on actual concentrations of poly cyclic aromatic hydro carbons (PAHs) in the human male fetal liver (Fowler et al. 2008) was striking. Eight of the PAH exposu...
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The nature of the exposure-response relationship has a profound influence on risk analyses. Several arguments have been proffered as to why all exposure-response relationships for both cancer and noncarcinogenic endpoints should be assumed to be linear at low doses. We focused on three arguments that have been put forth for noncarcinogens. First, the general "additivity-to-background" argument ...
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A 140 volume 117 | number 4 | April 2009 • Environmental Health Perspectives PAH Exposure doi:10.1289/ehp.0800445 We were very interested to read the article by Choi et al. (2008). The difference between maternal exposure and our own data on actual concentrations of poly cyclic aromatic hydro carbons (PAHs) in the human male fetal liver (Fowler et al. 2008) was striking. Eight of the PAH exposu...
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While radiobiological data are conveniently fitted by a linear quadratic formula to data of limited dynamic range at doses typically exceeding 1 Gy, they are extrapolated linearly to doses below a milligray for the evaluation of low dose RBEs. However a single relativistic electron passing through a cell nucleus deposits a “dose” there in the neighborhood of a milligray. The validity of the lin...
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If a FIFO queue is fed by several input streams that jointly satisfy a sample path large deviation principle (LDP) withìinear geodesics', then the cumulative departures (upto a large time) also satisfy the LDP with a rate function which depends in a relatively simple way on the rate function corresponding to the inputs: this was demonstrated in a recent paper by the second author. It suggests t...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2009
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.0800329